Webflll32是姜黄素的小分子类似物，它可以抑制stat3的信号转导和活化。在pstat3阳性的a375细胞系，flll32导致促凋亡作用，48小时的ic50值为1.3 μm[1]。在黑色素瘤中，stat3的激活与预后不良相关。stat3能促进血管生成和细胞增殖、推动侵袭和转移，抑制凋亡[1]。在多种人类黑素瘤细胞系中， flll32处理24小时 ... WebSTAT3 associates with Glut5 promoter and activates Glut5 transcription in response to IL-6. (A-B) DU145 and HSC-3 cells were stimulated with IL-6 (50 ng/mL) for the indicated periods of time.
美国APExBIO中文官网 - FLLL32 CAS# 1226895-15-3
WebAntibodies against phosphorylated signal transducer and activator of transcription 3 (pSTAT3) and enhancer of zeste homolog 2 (EZH2) were used for chromatin-immunoprecipitation sequencing (ChIP-seq) to detect the downstream epigenomic targets in the JAK2–STAT3 signaling pathway. WebSTAT3 is constitutively activated in many cancers and regulates gene expression to promote cancer cell survival, proliferation, invasion, and migration. In diffuse large B cell … hard disk not showing in device manager
Asymmetric Action of STAT Transcription Factors Drives ... - PubMed
WebMay 19, 2015 · To evaluate the specificity and redundancy for these cytokines, we quantified their global transcriptomic changes and determined the relative contributions of STAT1 and STAT3 using genetic models and chromatin immunoprecipitation-sequencing (ChIP-seq) … WebDec 1, 2024 · The ChIP assay results confirmed that pY705-STAT3 was required for the binding of STAT3 to the Twist1 promoter (Fig. (Fig.5C). 5C). Subsequently, the expression of mesenchymal markers such as Twist1 and vimentin was enhanced, and the expression of E-cadherin was suppressed (Fig. 5D, E ). WebFeb 27, 2024 · ChIp analyses indicated the binding of p53 to the promoter region of miR-199a-3p. Consistently, kidney biopsies from patients with IgA nephropathy and diabetic nephropathy exhibited substantial activation of p53 and STAT3, decreased expression of SOCS7, and increase in profibrotic proteins and miR-199a-3p. hard disk not showing in laptop